Synopses & Reviews
In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from the most recent recommendations for vitamin D intake to new approaches for the treatment and prevention of vitamin D deficiency and the development of active vitamin D drugs to treat psoriasis and cancer. The book demonstrates the significant role that vitamin D has in maintaining good bone health and the prevention of osteoporosis, an important health problem for adults over the age of fifty. In addition, it authoritatively reviews the relationship between sunlight exposure, vitamin D, and increased risk of colon and breast cancer; how vitamin D is made in the skin; and the sequence of events that leads to its activation by the kidney. Also examined are the biological functions of 1,25-dihydrovitamin D3 on the intestine and bone, as well as other tissues, such as skin, the immune system, prostate, and breast, and vitamin D's molecular mechanism of action on the cell membrane and nucleus. The first edition of Vitamin D: Physiology, Molecular Biology and Clinical Applications was the benchmark in the field when published in 1999. This new and expanded volume continues to include extensive, in-depth chapters covering the most important aspects of the complex interactions between vitamin D and other dietary components, the ongoing debate concerning the best indicator of optimal vitamin D status and its nutrient requirements, and the impact of less than optimal status on disease risk. Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition is designed and organized not only to be an up-to-date review on the subject, but also to provide medical students, graduate students, health care professionals and even the lay public with a reference source for the most up-to-date information about the vitamin D deficiency pandemic and its clinical implications for health and disease.
Review
From the reviews of the second edition: "This comprehensive book covers everything that is currently known about Vitamin D. It discusses topics ranging from the molecular biology of vitamin D and its role in human physiology to its role in health and disease. ... an extremely wide audience would find it useful: graduate students, medical students, healthcare professionals, nutritionists, and the lay public. ... The book reads consistently and easily from cover to cover, making it accessible to both scientists and nonscientists." (Heather Huang, Doody's Review Service, August, 2010) "This valuable and comprehensive monograph is divided in seven parts dealing with introduction and basic biology ... . This monograph contains numerous instructive figures, schemes and microphotos which help to understand sophisticated biological and technical processes representing the contemporaneous armament being used in this newly and rapidly development field of diabetology." (Endocrine Regulations, Fall, 2010)
Review
From the reviews of the second edition:
"This comprehensive book covers everything that is currently known about Vitamin D. It discusses topics ranging from the molecular biology of vitamin D and its role in human physiology to its role in health and disease. ... an extremely wide audience would find it useful: graduate students, medical students, healthcare professionals, nutritionists, and the lay public. ... The book reads consistently and easily from cover to cover, making it accessible to both scientists and nonscientists." (Heather Huang, Doody's Review Service, August, 2010)
"This valuable and comprehensive monograph is divided in seven parts dealing with introduction and basic biology ... . This monograph contains numerous instructive figures, schemes and microphotos which help to understand sophisticated biological and technical processes representing the contemporaneous armament being used in this newly and rapidly development field of diabetology." (Endocrine Regulations, Fall, 2010)
Synopsis
The goal of this book is to have the authors write in a crisp and concise fashion a summary of the most important and biologically relevant developments and the clinical importance of vitamin D in their particular area of expertise. The Editor is not interested in this book being an encyclopedia of information, but rather a user friendly source that basic scientists, nutritionists, health care professionals and specialists in calcium, vitamin D, and bone health can draw upon for useful up-to-date information on vitamin D and health.
Synopsis
This is a comprehensive overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics range from recommendations for vitamin D intake to treatment and prevention of deficiency and development of active vitamin D drugs.
Table of Contents
Dedication to Louis V. Avioli Steve Teitelbaum
A. Introduction and Basic Biology
1. Vitamin D and Health: Evolution, Biologic Functions, and Dietary Requirements for Vitamin D Michael F. Holick
2. Photobiology of Vitamin D Tai C. Chen, Zhiren Lu and Michael F. Holick
3. The Functional Metabolism and Molecular Biology of Vitamin D Action Lori A. Plum and Hector F. DeLuca
4. Metabolism and Catabolism of Vitam D, its Metabolites and Clinically Relevant Analogs Glenville Jones
5. The Molecular Biology of the Vitamin D Receptor Diane R. Dowd and Paul N. MacDonald
6. VDR and RXR Subcellular Trafficking Julia Barsony
7. Mechanism of Action of 1,25-Dihydroxyvitamin D3 on Intestinal Calcium Absorption and Renal Calcium Transport Dare Ajibade, Bryan S. Benn and Sylvia Christakos
8. Biologic and Molecular Effects of Vitamin D on Bone Martin A. Montecino, Jane B. Lian, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen, Fernando Cruzat
9. Biologic and Molecular Effect of Vitamin D on the Kidney Adriana S. Dusso and Masanori Tokumoto
10. Vitamin D and the Parathyroids Justin Silver and Tally Naveh Many
11. Diversity of Vitamin D Target Genes Carsten Carlberg
B. Non-skeletal/Functions of Vitamin D
12. Extra Renal Synthesis of 1,25-Dihydroxyvitamin D and Health Implications Daniel D. Bikle
13. Vitamin D and the Innate Immunity Philip Liu, Martin Hewison, John S. Adams
14. Vitamin D and Colon Cancer Heidi S. Cross and Meinrad Peterlik
15. Mechanisms of Resistance to Vitamin D action in Human Cancer Cells Maria Jesus Iarriba and Alberto Munoz
16. Vitamin D and the Brain: A Neuropsychiatric Perspective Louise Harvey, Thomas Burne, Xiaoying Cui, Alan Mackay-Sim, Darryl Eyles and John McGrath
17. Vitamin D Modulation of Adipocyte Function Michael B. Zemel and Xiaocun Sun
C. Vitamin D Status - Global Analysis
18. Determinants of Vitamin D Intake and Vitamin D Deficiency in the United States Mona S. Calvo and Susan J. Whiting
19. 25-hydroxyvitamin D Assays and Their Clinical Utility Neil C. Binkley and Gary Leusmeyer
20. Health Disparity and Vitamin D Deficiency in the United States Douglass Bibuld
21. Vitamin D Deficiency and its Health Consequences in Canada David A. Hanley
22. Vitamin D Deficiency and its Health Consequences in Northern Europe Leif Mosekilde
23. Vitamin D Deficiency and its Health Consequences in Mediterranean Countries Jose Manuel Quesada Gomez and Manuel Diaz-Curiel
24. Vitamin D Deficiency in the Middle East and its Health Consequences for Children Ghada El-Hajj Fuleihan
25. Vitamin D Deficiency in the Middle East and its Health Consequences for Adults El-Kaissi Samer and Suphia Sherbeeni
26. Vitamin D Deficiency and its Health Consequences in Africa Ann Prentice, Inez Schoenmakers, Kerry Jones, Landing Jarjou, Gail Goldberg
27. Vitamin D Deficiency and its Health Consequences in India R.K. Marwaha and R. Goswami
28. Vitamin D Deficiency, Rickets and Flourosis in India CV Harinaragan, CV and Shashank R Joshi
29. Vitamin D Deficiency and its Health Consequences in Asia Tim Green and Bernard Venn
30. Vitamin D Deficiency and its Health Consequences in New Zealand Mark J. Boland Ian R. Reid
31. Toxicity of Vitamin D Reinhold Vieth
D. Health Consequences of Vitamin D Deficiency and Resistance on Musculoskeletal Health
32. Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences Sarah N. Taylor, Carol L. Wagner, Bruce Hollis
33. Vitamin D Deficiency in Children and its Health Consequences Amy D. DiVasta, Kristen K. van der Veen, Catherine M. Gordan
34. Dietary Calcium Deficiency and Rickets John M. Pettifore, Philip R. Fischer, Tom D. Thacher
35. Vitamin D in Fracture Prevention and Muscle Function and Fall Prevention Heike A. Bischoff-Ferrari
36. Inherited Defects of Vitamin D Metabolism Marie Demay
37. Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihyroxyvitamin D Resistant Rickets (HVDRR)
38. Receptor-Independent Vitamin-D Resistance in Subhuman and Human Primates John S. Adams, Hong Chen, Thomas S. Lisse, Rene F. Chun, Martin Hewison
39. 25-Hyroxyvitamin D-1a-hydroxylase: Studies in Mouse Models and Implications for Human Disease
E. Sunlight, Vitamin D and Cancer
40. The Health Benefits of Solar Irradiance and the Consequences of its Deprivation William B. Grant
41. Vitamin D Status, Solar Radiation and Cancer Prognosis Johan Moan, Oyvind Sverre Bruland, Arne Dahlback, Asta Juzeniene and Alina Carmen Porojnicu
42. Epidemiology of Vitamin D and Cancer Edward Giovannucci
43. Vitamin D Deficiency and the Epidemiology of Prostate Cancer Gary Schwartz
44. Vitamin D for Cancer Prevention and Survival Edward D. Gorham, Sharif B. Mohr, Frank C. Garland and Cedric F. Garland
45. The Anti-Cancer Effect of Vitamin D: What do the Randomized Trials Show? Joan M. Lappe and Robert P. Heaney
46. Sunlight, Skin Cancer and Vitamin D Jorg Reichrath
F. Vitamin D Deficiency and Chronic Disease
47. Vitamin D and Risk of Type 1 Diabetes Elina Hypponen
48. Vitamin D and Multiple Sclerosis Alberto Ascherio and Kassandra L. Munger
49. Vitamin D and Type II Diabetes Myrto Eliades and Anastassios G. Pittas
50. Role of Vitamin D for Cardiovascular Health Robert Scragg
51. Vitamin D, Renin and Blood Pressure Yan Chun Li
52. Role of Vitamin D and Vitamin D Analogues for Bone Health and Survival in Chronic Kidney Disease Ishir Bhan, Hector Tamez and Ravi Thadhani
53. Role of Vitamin D and Ultraviolet Radiation in Chronic Kidney Disease Rolfdieter Krause
54. Role of Vitamin D in Rheumatoid Arthritis Linda A. Merlino
55. Vitamin D, Respiratory Infections and Obstructive Airway Diseases Carlos Carmago, Jr., Adit A. Ginde, Jonathan M. Mansback
G. Clinical Uses of Vitamin D Analogues
56. Treatment of Immuno-mediated Diseases by Vitamin D Analogues
57. Clinical Utility of 1, 25-Dihydroxyvitamin D3 and its Analogues for the Treatment of Psoriasis Jorg Reichrath and Michael F. Holick
58. Affinity Aklylating Vitamin D Analogs as Molecular Probes and Therapeutic Agents Rahul Ray
59. Anti-inflammatory Activity of Calcitriol that Contributes to its Therapeutic and Chemopreventive Effects in Prostate Cancer Aruna V. Krishnan and David Feldman